Day 1 :
DoctorJarret PLLC, USA
Time : 09:50-10:35
Jarret “Doctor Jarret” Patton MD has served thousands of children in eastern Pennsylvania for nearly 20 years. Throughout his career, he has remained an advocate for children’s health issues. Over time, his servant leadership style led him to curtail clinical practice to become a change agent in the healthcare system. As a former President of the Medical Staff at an eight hospital system in eastern Pennsylvania he worked with other leaders to promote children’s health and health equity in a highly matrixed environment. He advised organizations on a national level including The Joint Commission, American Hospital Association and the American Academy of Pediatrics. He has published in the medical literature and is the #1 best-selling author of Licensed To Live and Whose Bad @$$ Kids Are Those? He is the founder and CEO of DoctorJarret PLLC, a coaching and consulting firm which helps educate, enlighten and improve healthcare
Physician burnout has long been a problem in the United States and abroad. The changing milieu of the healthcare environment in addition to the hostile environment towards physicians has made the career less desirable by many. With so many things that leave physicians vulnerable including patient satisfaction, disciplinary boards and criminal proceedings, it doesn’t surprise you that many physicians are choosing to refresh or restart their careers in other areas. With the current shortage of physicians in the US coupled with the reduction of physicians in the clinical pipeline, one can wonder what will happen with the profession as we know it. While physicians are leaving the clinical workforce, others are finding other options more feasible leading to suicide or substance abuse. Now is the time to keep yourself healthy and take a long look at your career so that it doesn’t take over your life entirely.
Montgomery College, USA
Children’s Hospital of Philadelphia, USA
Sharon Diskin completed her PhD in 2008 from the University of Pennsylvania and postdoctoral studies at The Children’s Hospital of Philadelphia in 2012. She is an Assistant Professor of Pediatrics at the University of Pennsylvania and Children’s Hospital of Philadelphia. Her research program is focused on identifying the genetic basis of childhood cancers, including the complex interplay between germline and tumor genomics. She has published more than 47 papers in reputed journals and serves as a reviewer or editorial board member of multiple journals.
Neuroblastoma is a malignancy of the developing sympathetic nervous system which accounts for 12% of childhood cancer deaths. Appoximately 1-2% of cases are inherited in an autosomal dominant fashion and mutations in ALK and PHOX2B have been identified as the major drivers of this subset. Here, we report on efforts to identify the genetic basis of sporadic neuroblastoma (98% of cases) using a combination of genome-wide association studies (GWAS) and next generation sequencing. To date, we have genotyped 6,201 neuroblastoma cases and 32,240 healthy controls for GWAS and performed whole-genome or whole-exome sequencing (WGS or WXS) on matched tumor-normal DNA pairs from 776 cases to identify rare germline mutations. GWAS efforts have led to the publication of over a dozen susceptibility loci and the identification
of genes influencing both tumor initiation and progression. We have now performed a large multi-ethnic GWAS combining cohorts of European ancestry, African American and Hispanic populations. We identified eleven new susceptibility loci (P < 5.0 x 10-8) and discovered a rare 550-kb deletion on chromosome 16p11.2 enriched in cases vs. controls (Odds Ratio: 15.4; 95% C.I. 4.1-57.9). From sequencing studies, we observed enrichment of truncating BARD1 mutations in neuroblastoma cases (1.2%, p<0.001) and estimate that ~10% of children with neuroblastoma harbor a rare pathogenic germline mutation in a known cancer predisposition gene. Collectively, these studies are defining the landscape of genetic predisposition in neuroblastoma. Ongoing efforts are focused on identifying the functional significance of rare germline mutations and translating these findings to the clinic.
Emeritus Professor, USA
Igor Klepikov who is now retired has worked as a Professor in Kemerovo State Medical Academy, Russia.
Treatment of acute pneumonia (АР) in recent decades focused solely on antibiotic therapy, does not include pathogenetic, specific methods of assistance and repeats the principles of treatment of other inflammatory diseases. Reducing the effectiveness of antimicrobial drugs, the emergence and the increasing number of antibiotic-resistant pathogens and a gradual increase in the frequency of purulent complications attach importance and urgency to the solution of this problem. The first step in this decision is a revision of ideas about the nature and mechanisms of АP. This work has been done and tested in a clinical setting in the years 1976-1984 in Novokuznetsk State Institute for postgraduate doctors (USSR, Russia). The basis of the new doctrine АP was based on the following scientific medical axioms, already having previous scientific justification.
1. The body's response to any stimulus, including the initiation of inflammation, is highly individual and unique.
2. The basis for the inflammatory transformation of the body tissue is a vascular reaction with a specific stage sequence.
3. Small and big circles of blood circulation not only have a direct relationship but an inverse relationship.
4. Among the nonspecific forms of inflammation, AP is the only process occurring in the system of lesser circulation.
5. The same medical procedure can have different effects on inflammation in the small or big circles of blood circulation.
Following private studies were additionally performed:
1. An experimental model of AP (4 series of experiments, 44 animals) obtaining a model of pleural complications (certificate for invention No 1631574, A1,1 November 1990, USSR).
2. X-ray examination 56 lung anatomical preparations with different forms of the AP, taken from the dead patients.
3. Record comparative rheopulmonography before and after performing medical procedures(36 patients).
Analysis of the observation and treatment of 994 children with AP and it's various destructive and pleural complications. The revised treatment guidelines were applied in 101 patients in the initial period of aggressive forms of АP. The received results allow speaking about the possibility of the guaranteed prevention of suppurative and destructive complications of the disease. A more detailed presentation and justification of the new doctrine AP, the results of these studies and clinical trials can be found in the published book: Igor Klepikov-"Acute pneumonia: A new look at the old problem", Lambert Academic Publishing, 2017, ISBN (978-3-330-35250-6). This book gives a detailed understanding of the unique mechanisms in the development of AP and the existing ways of influencing them in the direction of stimulation and inhibition. Materials give a real idea about the possibility of guaranteed prevention of suppurative and destructive complications of the disease.